Tobacco Addiction - Blame it on Genes!

Reena Kandyala, Govind Rajkumar Nalabolu, Soujanya Pinisetty, Saraswathi Thillai Rajashekaran

Abstract


Tobacco use, in any form, either smoked or smokeless, is of a major concern to the dentist as it can cause a wide spectrum of oral mucosal lesions. As the multiple oral and systemic health effects of tobacco usage have been extensively explored and reported, the dentists are well aware of them, but have only limited understanding of the complex biological mechanisms of nicotine addiction. Dependence on tobacco, like many other drug dependencies, is a complex behavior with both genetic and environmental factors contributing to it. The purpose of the present article is to familiarize dentists with the current concepts on the mechanisms involved in initiation, maintenance, cessation, relapse and various therapeutic approaches of the habit.


Keywords


Tobacco;Addiction;Nicotine;Dopamine;Dopaminergic Receptors;Candidate Genes.

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