Estimation of Serum Lipid Peroxides Before and After Radiotherapy in Oral Squamous Cell Carcinoma Patients

Mahendra Ramdas Patait, Rajendra N Mody, Shruti Khanzode


Background: Oral Cancer is a term used to identify those malignant tumors which originate in the mucous membrane lining the oral cavity. Many researchers have shown that lipid peroxides (Malondialdehyde) are the products of the chemical damage done by oxygen free radicals, to the lipid components of cell membrane and showed discrepancies in its serum values in radiation treated malignant cases. Present study was conducted with the aim to estimate and compare the serum malondialdehyde level in normal individuals, oral cancer patients before and after radiotherapy. Aims and Objectives: 1. To estimate and compare serum Malondialdehyde level of normal healthy individuals with that of oral Squamous cell carcinoma patients. 2. To estimate and compare serum Malondialdehyde level in the oral Squamous cell carcinoma patients before and after radiotherapy. Materials and Methods: In this study serum malondialdehyde was measured according to Kei Satosh Method in 20 normal individuals and 20 patients each with histopathologically diagnosed oral cancer. Results: The mean serum MDA level in the pre-radiotherapy study group was 0.598 ± 0.1609 which was significantly higher than control group 0.3084 ± 0.1016 and the mean serum MDA level in the study group after radiotherapy was 0.792 ± 0.1157 which was higher as compared to pre-radiotherapy mean serum level of 0.598 ± 0.1609.. Conclusion: Thus it can be concluded that the mean serum MDA level increases in the oral squamous cell carcinoma patients as compared to the healthy individuals and this level further increase after the radiotherapy which indicates more damage to the cellular structure from free radicals leading to oxidative stress. This increase in oxidative stress in serum MDA level again suggests the requirement of an adjunct therapyto treat the oral squamous cell carcinoma along with radiotherapy.


Malondialdehyde; Lipid Peroxidation; Oral Cancer; Blood Serum; Plasma; Squamous Cell Carcinoma; Radiotherapy

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