Altered C-Reactive Protein Levels in Serum of Oral Precancer Patients in Comparison With Healthy Controls

Anand Kumar, Sumit Bhateja


Background: The role of inflammation in cancer is not well established although some organs of the body show greater risk of cancer when they are chronically inflamed. Recent advances in understanding complex tumor interactions have led to the discovery of an association between inflammation and cancer, in particular for colon and lung cancer, but only a very few have dealt with oral cancer & none with oral precancers. Aims & Objectives: To investigate pretreatment C-reactive protein (CRP) levels in oral precancers & evaluate their usefulness as prognostic markers. Materials and Methods: The study sample consisted of 25 control and 25 oral precancer patients (Leukoplakia, OSMF & Oral lichen planus) confirmed by histopathological examination. All samples were subjected to CRP analysis. Results: Highly significant differences in mean CRP levels were found (p=0.00) between control versus study group. Conclusion: Our findings demonstrate that prediagnostic concentrations of CRP are strongly associated with subsequent development of oral cancer.


C-Reactive Protein;Precancerous Conditions;Oral Cancer;Head & Neck Neoplasms; Inflammation;Leukoplakia;Oral Lichen Planus;Oral Submucous Fibrosis.

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