A Clinico-Pathological and Immunohistochemical Study of Salivary Gland Tumors: A 5 Year Indian Experience

Vineet Gupta, Pratibha Ramani, Chandrasekar T


Objectives: To report the clinico-pathological data of salivary gland tumors in Indian population and evaluate common salivary gland tumors using the immunohistochemical markers namely Smooth muscle actin. Materials and Methods: The files from 2004 to 2008 were searched for cases coded as salivary gland tumors. Results: A total of 1855 biopsy specimens were accessioned during the study period. 37 cases were of salivary gland neoplasms, from which 11 were benign and 26 were malignant in nature. Rare presentation of Polymorphous low grade adenocarcinoma in the lower lip and sub-mandibular region has also been reported here. Conclusion: The incidence of malignancies in our cases was higher than benign salivary gland neoplasms. In contrast to the previously existing literature, two unusual presentations have been noticed i.e. third case of Polymorphous low grade adenocarcinoma to be reported in the lower lip and fourth case in the submandibular region. Immunohistochemically, stromal myofibroblasts could be demonstrated only in the tumors with malignant potential. Aggressiveness & prognosis of the tumors can be predicted by measuring the density of myofibroblasts at the invasive front.



Salivary Gland Neoplasms;Parotid Neoplasms;Sublingual Gland Neoplasms; Submandibular Gland Neoplasms;Clinico-Pathological Study;Immunohistochemistry.

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