Orthokeratinized Odontogenic Cyst of the Mandible: A Case Report

Simarpreet Virk Sandhu, Sudesh K Rao, Ramandeep Singh Brar, Tushar Kakkar


Orthokeratinized odontogenic cyst (OOC) is a developmental cyst that occurs in the maxilla and the mandible and was initially defined by the World Health Organization as the uncommon orthokeratinized type of odontogenic keratocyst (OKC). However, studies have shown that OOC has peculiar clinicopathologic aspects when compared with other developmental odontogenic cysts, especially OKCs. The orthokeratinized odontogenic cyst is a distinct clinicopathologic entity and is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent granular cell layer. The basal cells are usually cuboidal or flattened. Clinically, the orthokeratinized cyst is a single cyst, shows a predilection for males, and is most often found in the second to the fifth decade. It is not dentigerous cyst but is often mistaken for a dentigerous cyst in the posterior mandible and exhibits little clinical aggressiveness. The purpose of the article is to present a case of OOC arising in the posterior mandible and highlight the importance of distinguishing it from the more commonly occurring Keratocystic Odontogenic Tumour.


Jaw Cysts;Odontogenic Cyst;Basal Cell Nevus Syndrome;Odontogenic Keratocyst; Dentigerous Cyst;Secretory granules

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