Association between Dental Caries and Lipid Peroxidation in Saliva

Gargi Sarode, Anjali Shelar, Sachin Sarode, Neeta Bagul


The aim of the present study was to evaluate the relationship between salivary malondialdehyde (MDA) ie oxidative stress and oral health. Healthy adults, matched for gender and age, with (N = 30, 13 males and 17 females with mean age of 27.56 years) and without (N = 12, 6 males and 6 females with mean age of 26.1 years) dental caries were included in this study. The World Health Organization caries diagnostic criteria were used for determining the decayed, missing, filled teeth (DMFT) index and oral hygiene was assessed using the simplified oral hygiene index (OHI). Lipid peroxidation (LP) was determined by Buege and Aust method. Simplified oral hygiene index and DMFT scores were significantly different between the groups. MDA values were significantly different (P < 0.05) between the groups (0.6242 ± 0.1001 and 1.699 ± 0.2088 in adults without caries and with caries, respectively). MDA values were increasing with higher OHI but were not statistically significant. Our results suggest that there is an association between presence of dental caries and salivary MDA levels.


MDA; Lipid peroxidation; Dental caries; Oral health

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