Dental Surgeons as Gene Therapist

Paramel Mohan Sunil, Ramachandran CR, Jaisanghar N, Santhosh Kumar C

Abstract


Gene therapy is a particular method by which defective gene is replaced or repaired by therapeutic gene. Vectors are vehicles which deliver the therapeutic gene into the host. Gene therapy can be used to treat wide range of diseases ranging from single gene disorder to multi-gene disorder. In dentistry the application of gene therapy includes bone repair, for treating auto immune disease, pain, DNA vaccination (for caries and periodontal disease) and cancer. Minor salivary glands and keratinocytes present in the oral mucosa are the excellent target sites for gene therapy since it can be readily accomplished with minimal invasive manner. This makes dentists as suitable candidate for gene therapy.


Keywords


Therapy;Gene;DNA;Somatic;Genetic Services;Biological Therapy;Vaccination; Immunotherapy;Oral Cancer;Vector.

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