Different Histolopathologic Features of Pleomorphic Adenoma in Salivary Glands

Mahmood Jahangirnezhad, Saedeh Atarbashi Moghadam, Sepideh Mokhtari, Shirin Taravati


Background: Pleomorphic adenoma is the most common salivary gland tumor. It is composed of varying proportions of epithelial and myoepithelial cells that are arranged in a great variety of morphological patterns. Therefore, it has a diverse histological presentation that may cause diagnostic problems with other salivary gland tumors. Purpose of Study: The objective of this study was to assess the different histopathological features of pleomorphic adenoma in salivary glands. Materials and Methods: Fifty specimens of pleomorphic adenoma were analyzed. All the cases were primary neoplasms and excisional biopsies. The tumors were classified as stroma-rich, cell-rich and classic (balanced amount of epithelial and stromal component).The mesenchymal component was divided into myxoid, chondroid, hyaline, fatty and calcified tissue. The parenchymal component was analyzed according to presence of spindle, plasmacytoid, basaloid, squamous, cubic, mucous and oncocytoid cells. The architectural pattern was divided in to ductal, solid and trabecular. Presence of capsule was also analyzed. Results: The most common pattern was cell-rich (38%). Myxoid (78%) and Hyalinized (56%) stroma were the most frequent mesenchymal tissues. Spindle shaped (92%) and plasmacytoid (86%) cells were also the most common cell types. Ductal (72%) and solid (66%) structures were the most frequent patterns. All specimens had capsule. There was no evidence of cellular atypia or necrosis in all cases. Conclusion: The knowledge about various microscopic patterns of pleomorphic adenoma is essential and helps to have a proper diagnosis and better treatment.


Complex and Mixed Neoplasms; Histopathology; Mixed Tumor; Myoepithelial Tumor; Pleomorphic adenoma; Salivary Gland Tumors;

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