Pedunculated Desmoplastic Fibroblastoma (Collagenous Fibroma) of the Oral Cavity: A Previously Unreported Clinical Presentation

Bruno Correia Jham, Anna Carolina Mesquita, Renata Gonçalves Resende, Ricardo Alves Mesquita


Desmoplastic fibroblastoma is a rare, benign, soft tissue tumour. To our knowledge, six cases of Desmoplastic fibroblastoma in the oral cavity have been described so far, all with a sessile clinical configuration. Here, we describe the seventh case of oral Desmoplastic fibroblastoma, the first one presenting as a pedunculated nodule. A 56-year-old female sought care for evaluation of a nodule on the palate. No radiographic changes were noted. Excision of the lesion was performed and microscopic examination revealed a fibroblastic proliferation in the lamina propria. Immunohistochemistry showed positivity for vimentin and some positive cells for α-smooth muscle actin and factor XIIIa, confirming the diagnosis of desmoplastic fibroblastoma. This paper expands the spectrum of clinical manifestations of oral Desmoplastic fibroblastoma and demonstrates that this lesion should be included in the differential diagnosis of pedunculated intra-oral lesions.


Case Report; Collagenous Fibroma; Desmoplastic Fibroblastoma; Oral Cavity; Vimentin; Pedunculated.

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