Cutaneous Extramedullary Plasmacytoma with Multiple Nodular Skin Lesions with an unexpected involvement of lip
Extramedullary Plasmacytoma of the skin is a rare condition especially appears with multiple skin nodules localised on chest, back, and abdomen. Here, we report a case of 47-year-old man with known extramedullary plasmacytoma who had a cervical mass initially. The patient developed cutaneous lesions on the lip, scalp, chest wall and leg in the course of the disease. Lip was an unusual involvement site in an unusual disease, cutaneous plasmacytoma. His bone marrow biopsy showed no myeloma infiltration. The histopathological diagnosis was IgGκ extramedullary plasmacytoma. Chemotherapy and radiotherapy was applied but treatment response was not good overall. Radiotherapy was effective in reducing tumor bulk and the pain associated with the lesions. However, the patient died five months later due to the systemic myeloma infiltration.
Nguyen SK, Dagnault A. Radiotherapy for multiple myeloma with skin involvement. Current Oncology 2010;17:74-7.
Bayer-Garner IB, Smoller BR. The spectrum of cutaneous disease in multiple myeloma. J Am Acad Dermatol 2003;48:497-507.
Kazakov DV, Belousova IE, Müller B, et al. Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long-term follow-up and review of the literature. J Cutan Pathol 2002;29(4):244-8.
Requena L, Kutzner H, Palmedo G et al. Cutaneous Involvement in Multiple Myeloma: A Clinicopathologic, Immunohistochemical and Cytogenetic Study of 8 Cases. Arch Dermatol 2003;139:475-86.
Switzer PK, Moseley V, Cannon WM. Extramedullary plasmacytoma involving pharynx, skin, and lymph nodes. AMA Arch Intern Med 1950;86:402-11.
Tsutani H, Sugiyama T, Shimizu S, et al. Discordant lfa-1/ icam-1 expression in a case of secondary plasma cell leukemia associated with subcutaneous plasmacytoma. Am J Hematol 1993;42:299–304.
Jurisica V, Colovic N, Konjevic G, Minica I, Colovic M. An Aggressive Extramedullary Cutaneous Plasmacytoma Associated with Extreme Alterations in the Innate Immune System. Onkologie 2010;33:113–5.
Goudie RB, Macfarlane PS, Lindsay MK. Homing of lymphocytes to non-lymphoid tissues. Lancet 1974;1:292–3.
Ioannidis O, Kakoutis E, Varnalidis I, et al. Giant cutaneous plasmacytoma of the sacrococcygeal region. J Cutan Med Surg 2010;14(2):90-4.
Siniscalchi A, Fratoni S, Santeusanio G, Del Poeta G, de Fabritiis P, Caravita T. Cutaneous involvement in multiple myeloma and bortezomib. Ann Hematol 2009;88:1137–9.
Stankler L, Davidson JF. Multiple extramedullary plasmacytomas of the skin: case report with a note on prognosis. Br J Dermatol 1974;90:217-21.
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