Oral Hairy Leukoplakia in a Patient with Systemic Primary Amyloidosis: A Case Report

Jeane de Fátima Correia-Silva, Renata Gonçalves Resende, Fernanda Maia Lodi, Brendan Conn, Ricardo Alves Mesquita, Ricardo Santiago Gomez


Oral hairy leukoplakia is characterized by an asymptomatic white plaque on the lateral borders of the tongue. It is associated with immunodeficiency, principally to Human Immunodeficiency virus infection, but it has also been reported in patients with other immunosuppressed states. A 48-year-old man with primary amyloidosis was referred to evaluate a white plaque on the tongue. Based on the patient’s clinical presentation, medical history, and localization of the oral lesion, differential clinical diagnosis included amyloidosis, oral hairy leukoplakia, idiopathic leukoplakia, hyperplastic chronic candidiasis, and uremic stomatitis. The diagnosis of oral hairy leukoplakia was confirmed by histopathological analysis and in situ hybridization showing Epstein-Barr virus. This is an unusual clinical presentation of oral hairy leukoplakia. 


Amyloidosis; Autologous; EBV; Oral Hairy Leukoplakia; Stem Cell; Transplantation.

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