Monophasic Synovial Sarcoma of Pharynx: A Diagnostic Challenge

Gurshinder Pal Singh, Sandeep Dachuri, Shaila T Bhat, Ankur Kaur Shergill


Synovial Sarcomas of the head and neck region are very rare. The histologic monophasic variant of this tumor in the pharynx is even more uncommon. The benign appearance of an otherwise aggressive neoplasm offers a diagnostic challenge to both the surgeons and pathologists worldwide. Immunohistochemistry augments the conventional histopathology and offers a definitive diagnosis. Surgery forms the main mode of treatment followed by adjuvant radiotherapy. A rare case of monophasic synovial sarcoma of pharynx of a young boy is reported here. Any benign appearing chronic lesion with sudden exacerbation in head and neck region in young age group should be envisaged with high index of suspicion.


Diagnosis; Immunohistochemistry; Pharynx; Sarcoma; Synovial; Radiotherapy.

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Betal D, Babu R, Mehmet V. Monophasic synovial sarcoma of the pharynx: a case report. Int Semin Surg Oncol 2009;6:9.

McCarville MB, Spunt SL, Skapek SX, Pappo AS. Synovial sarcoma in pediatric patients. Am J Roentgenol. 2002;179:797–801.

Alberty J, Dockhorn-Dwornicak B. Monophasic synovial sarcoma of the neck in a 8-year-old girl resembling a thyroglossal duct cyst. Int J Pediatr Otorhinolaryngol 2002;63:61-5.

Artico R, Bison E, Brotto M. Monophasic synovial sarcoma of hypopharynx: case report and review of literature. Acta Otorhinolaryngol 2004;24:33-6.

Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM. Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 2007;29:731-40.

Hirsch RJ, Yousem DM, Loevner LA, et al. Synovial sarcomas of the head and neck: MR findings. Am J Roentgenol 1997;169:1185–8.

Sigal R, Chancelier MD, Luboinski B, Shapeero LG, Bosq J, Vanel D. Synovial sarcomas of the head and neck: CT and MR findings. Am J Neuro Radiol 1992;13:1459–62.

Rangheard A, Vanel D, Viala J, Schwaab G, Casiraghi O, Sigal R. Synovial sarcomas of the head and neck: CT and MR imaging findings of eight patients. Am J Neuro Radiol 2000;22:851–7.

Guillou L, Wadden C, Kraus MD, Dei Tos AP, Fletcher CDM. S-100 protein reactivity in synovial sarcomas: a potentially frequent diagnostic pitfall; immunohistochemical analysis of 100 cases. Appl Immunohistochem 1996;4:167-175.

Pelmus M, Guillou L, Hostein I, Sierankowski G, Lussan C, Coindre JM. Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases. Am J Clin Pathol 2002;26:1434-1440.


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