Cotrimoxazole Induced Erythema Multiforme
Erythema Multiforme is an acute inflammatory disease of the skin, considered to be hypersensitivity reaction to infection and drugs. Sulfa drugs are the most common triggers considered. Here is the case of Erythema multiforme secondary to drug reaction from cotrimoxazole. Patient had oral and skin manifestations and was treated with systemic corticosteroids. No complications were seen on further follow-up.
Huff JC, Denver MC. Aciclovir for recurrent erythema multiforme caused by Herpes simplex. J Am Acad Dermatol. 1988;18:197-9.
Von Hebra F. On diseases of skin including the exanthema. Trans by Fagge CH. London: New Syndenhan Society; 1966;1:285-9.
Wetter DA, Davis MD. Recurrent erythema multiforme: clinical characteristics, etiologic associations, and treatment in a series of 48 patients at Mayo Clinic, 2000–2007. J Am Acad Dermatol. 2010;62:45–53.
Volcheck GW. Clinical evaluation and management of drug hypersensitivity. Immunol Allergy Clin North Am. 2004;24:357-71.
Farthing P, Bagan JV, Scully C. Mucosal disease series. Number IV. Erythema multiforme. Oral Dis. 2005;11(5):261-7.
Lamoreux MR, Sternbach MR, Hsu WT. Erythema multiforme. Am Fam Physician. 2006;74(11):1883-8.
Ignacio GD, Laurence L, He’le’ne B, Xose LO, Jean CR. Toxic Epidermal Necrolysis and Stevens-johnson syndrome: does early with drawl of causative drugs decrease the risk of death. Arch Dermatol. 2000;136:323-7.
Arora VK, Venubabu K. Cotrimoxazole induced toxic epidermal necrolysis in a suspected case of Pneumocystis carinii pneumonia with human immuno deficiency virus infection. Indian J Chest Dis Allied Sci. 1998;40(2):125-9.
Habif TP. Hypersensitivity syndromes and vasculitis. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 4th ed. New York: Mosby; 2004:626-34.
Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-45.
Greenberg MS, Glick M, Burket's Oral medicine Diagnosis and Treatment. 10th Ed. Hamilton, Canada; BC Decker: 57-60.
Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick’s Dermatology in General Medicine. 6th ed. New York; McGraw-Hill: 2003 p 585-96.
Imafuku S, Kokuba H, Aurelian L, et al. Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions. J Invest Dermatol. 1997;109:550–6.
Aurelian L, Kokuba H, Burnett JW. Understanding the pathogenesis of HSV-associated erythema multiforme. Dermatology. 1998;197(3):219-22.
Sun Y, Chan RK, Tan SH, Ng PP. Detection and genotyping of human herpes simplex viruses in cutaneous lesions of erythema multiforme by nested PCR. J Med Virol. 2003;71:423–8.
Aurelian L, Ono F, Burnett J. Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): A viral disease with an autoimmune component. Dermatol Online J. 2003;9:1.
Kokuba H, Imafuku S, Huang S, Aurelian L, Burnett JW. Erythema multiforme lesions are associated with expression of a herpes simplex virus (HSV) gene and qualitative alterations in the HSV-specific T-cell response. Br J Dermatol. 1998;138:952–64.
Knowles SR, Uetrecht J, Sheas NH. Idiosyncratic drug reactions: the reactive metabolite syndromes. Lancet. 2000;356:1587–91.
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