Evaluation of Free Gingival Grafts as a Treatment for Gingival Involvement of Mucous Membrane Pemphigoid: Periodontal Considerations and a Study of Six Cases

Simon Jean, Geneviève Payne, Julien E. Ghannoum

Abstract


Background: Mucous membrane pemphigoid is a chronic autoimmune blistering disease of unknown aetiology. The attached gingiva in dentulous areas is one of the primary affected sites. Oral mucous membrane pemphigoid is often treated with hygiene measures in association with topical corticosteroids and/or immunosuppressive agents. Lesions can be temporarily controlled by medication but there is no definitive cure. Treatment is focused on treating active lesions and alleviating symptoms. Aims and Objectives: To assess free gingival grafts as a novel approach in the treatment of recalcitrant for oral mucous membrane pemphigoid lesions. Materials and Methods: Inflammation was subjectively graded using a visual analog scale preoperatively and three months after the free gingival grafts were performed. Patients were also re-evaluated six months postoperatively. Results: All patients displayed complete, albeit localized, permanent remission of lesions in the treated areas, despite discontinuation of topical treatment. Slight radial improvement around the gingival grafts was noted. Conclusion: Free gingival grafts could be useful in treating refractory gingival lesions due to mucous membrane pemphigoid. These results may help to shed deeper insight on the pathogenesis of this disease and help developing more specific therapies.


Keywords


Desquamative Gingivitis; Free Gingival Graft; Mucous Membrane Pemphigoid; Vesicullobullous Disease.

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References


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