A Short Review on Human Leukocyte Antigens and Oral Submucous Fibrosis

Vijaykumar Goudappagouda Biradar, Madhusudan SundarRao Astekar


Human leukocyte antigens are crucial components of host defense against microbial challenge but the associations of Human leukocyte antigens types with oral diseases have not been studied in detail. Oral submucous fibrosis is a complex, debilitating, and precancerous condition. Formerly confined to the Indian subcontinent, it is now often seen in the Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. Human leukocyte antigens typing reveals the genetic and molecular changes related to early, intermediate and late endpoints in the process of oral carcinogenesis. There are only few studies on the Human leukocyte antigens typing of oral submucous fibrosis in the worldwide in recent years. This article attempts to compile details of Human leukocyte antigens typing in Oral submucous fibrosis and summarize and infer on the findings.


Genetic Risk; Human Leukocyte Antigens; Molecular Changes; Major Histocompatibility Complex; Oral Submucous Fibrosis; Precancerous Condition

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