Calcifying Cystic Odontogenic Tumor Presenting as a Dentigerous Cyst: A Case Report with Literature Review

Ali Hanttash AbuHanttash, Aysegul Tuzuner Oncul, Umit Akal Aktaş

Abstract


The calcifying cystic odontogenic tumor is comparatively rare in occurrence, constituting about 1.6% - 4.3% of all odontogenic tumors. Various terminologies have been used to describe this rare odontogenic tumor, sometimes referred to as the “keratinizing and calcifying odontogenic cyst, Gorlin cyst, calcifying odontogenic cyst, calcifying ghost cell odontogenic tumor, dentinogenic ghost cell tumor, and epithelial odontogenic ghost cell tumor”. It is characterized by the presence of ghost cells with proliferative odontogenic epithelium and has a propensity for calcification. The aim of this paper is to report a case of calcifying cystic odontogenic tumor misdiagnosed as a dentigerous cyst in the posterior region of the mandible associated with unerupted tooth, along with a brief review of literature based on the term calcifying cystic odontogenic tumor. The lesion was surgically enucleated. After enucleation no recurrence has been observed during the follow up period of four years.


Keywords


Calcifying Cystic Odontogenic Tumour; Dentigerous Cyst; Ghost Cells; Hybrid Odontogenic Tumor; Odontogenic Tumors

Full Text:

PDF HTML XML

References


Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg 2006;64:1343-1352.

Habibi A, Saghravanian N, Salehinejad J, Jafarzadeh H. Thirty years clinic-pathological study of 60 calcifying cystic odontogenic tumor in iranian population. The Journal of Contemporary Dental Practice 2011;12(3):171-173.

Ledesma-Montes C, Gorlin RJ, Shear M, Prae Torius F, Mosqueda-Taylor A, Altini M. Inter- national collaborative study on ghost cell odontogenic tumours. Calcifying cystic odontogenic tumours, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma. Journal of Oral Pathology & Medicine 2008;37:302-308.

Shear M, Speight P. Cysts of the Oral and Maxillofacial Regions. 4th Edition. Blackwell-Munksgaard. 2007. p. 100- 107.

Zornosa X, Muller S. Calcifying cystic odontogenic tumor. Head & Neck Pathology 2010;4:292-294.

Manveen JK, Subramanyam RV, Simmerpreet SV, Ramandeep NS. Calcifying Cystic Odontogenic Tumour Mimicking as a Residual Cyst. Journal of Clinical and Diagnostic Research 2010;(4):2979-2983.

Ahn SG, Kim SA, Kim SG, Lee SH, Kim J, Yoon JH. Betacatenin gene alterations in a variety of so-called calcifying odontogenic cysts. APMIS. 2008;116:206–11.

Eshghyar N, Jalayer-Nadery N, Ashery R. Calcifying odontogenic cyst: an analysis of thirty-six cases. Acta MedicaIranica 2006;44(1):59–62.

Buchner A, Merrell PW, Carpenter WM. Relative frequency of peripheral odontogenic tumors: a study of 45 new cases and comparison with studies from the literature. J Oral Pathol Med 2006;35:385–391.

Resende RG, Brito JAR, Souza LN, Gomez RS, Mesquita RA. Peripheral calcifying odontogenic cyst: a case report and review of the literature. Head Neck Pathol 2011;5:76-80.

Taghavi N, Khodayari A, Sargolzaei S, Mashhadiabbas F, Moshref M, Lotfi A, et al. Recurrent Peripheral Calcifying Cystic Odontogenic Tumor (Calcifying Odontogenic Cyst). Iranian Journal of Pathology 2009;4(3):141-145.

Mittal N, Shah K, Chandra S, Gupta S, Mittal S, Agarwal M. Extraosseous calcifying cystic odontogenic tumor: An uncommon variant. National Journal of Maxillofacial Surgery 2013;4(2):245-248.

Menat S, Shylaja MD, Attur A, Goyal K. Ameloblastomatous CCOT: A case report of a rare variant of ccot with a review of the literature on its diverse histopathologic presentation. Case Reports in Dentistry 2013; 2013: ID 407656, 6 Pages

Chindasombatjaroen J, Poomsawat S, Kakimoto N, Shimamoto H. Calcifying cystic odontogenic tumor and adenomatoid odontogenic tumor: radiographic evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:796-803.

Tanimoto K, Tomita S, Aoyama M. Radiographic characteristics of the calcifying odontogenic cyst. International Journal of Oral and Maxillofacial Surgery 1988;17:29–32.

Santos T, Frota R, Andrade E, Oliveira E. Calcifying cystic odontogenic tumor radiographically mimicking a sinus mucocele. The Journal of Craniofacial Surgery 2013;24(2):134-6.

Estrela C, Decurcio DA, Silva JA, Mendonça EF, Estrela CRA. Persistent apical periodontitis associated with a calcifying odontogenic cyst. Int Endod J 2009;42(6):539-545.

Vasudev S, Singh VP, Jhawar R, Roy DK. Calcifying cystic odontogenic tumor- a unique developmental lesion arising in mandible. Health Renaissance 2012;10(1):64-68.

Moen K, Lybak S, Jonsson HS, Seland H, Størksen K, Johannessen AC, et al. Orbital reconstruction after resection of giant calcifying cystic odontogenic tumor of mid-face. J Oral Maxillofac Surg 2012;70:233-241.

Gong Y, Wang L, Wang H, Li T, Chen X. The expression of NF-kappa B Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol 2009;45.515–20.

Kikuchi K, Ito S, Inoue H, Alva PG, Miyazaki Y, Sakashita H. Immunohistochemical expression of podoplanin in so-called hard α-keratin- expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma. Journal of Oral Science 2012;54:165-75.

Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinase and TIMPs. Cardiovasc Res 2006;69.562-573.

Ribeiro B, Araújo C, Santos B, Freitas R. Immunohistochemical expression of matrix metalloproteinase 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(5):609-15.

Mokhtari S, Mohsenifar Z, Ghorbanpour M. Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature. Case Rep Pathol. 2013;2013, 6 pages

Goldenberg D, Sciubba J, Tufano RP. Odontogenic ghost cell carcinoma. Head Neck 2004;26.378-81.

Arashiyama T, Kodama Y, Kobayashi T, Hoshina H, Takagi R, Hayashi T, et al. Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. Oral and Maxıllofacıal Pathology 2012;114(3):35-40.

Basile JR, Klene C, Lin YL. Calcifying odontogenic cyst with odontogenic keratocyst: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:e40- 5.

Zhang LL, Yang R, Zhang Li W, MacDonald-Jankowski D, Poh CF. Dentigerous cyst: a retrospective clinic-pathological analysis of 2082 dentigerous cysts in British Columbia, Canada. Int J Oral Maxillofac Surg 2010;39.878-882.

Chindasombatjaroen J, Poomsawat S, Klongnoi B. Calcifying cystic odontogenic tumor associated with other lesions: case report with cone-beam computed tomography findings. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113(3):414- 16.

Jahanshahi G, Ardakani S. A pigmented calcifying cystic odontogenic tumor associated with odontoma: A Case Report. Journal of Isfahan Dental School 2009;5(1):49-53.

Sakai VT, Filho C, Moretti A, Pereira A, Hanemann J, Duque J. Conservative Surgical Treatment of an Aggressive Calcifying Cystic Odontogenic Maxillary Tumor in the Young Permanent Dentition. Pediatric Dentistry 2011;33(3):265-269.

Schuster D, Joel C, Brad W. Transnasal endoscopic resection of a calcifying cystic odontogenic tumor. Ear, Nose, & Throat Journal 2014;93(8):E28-30.

Souza LN, Souza ACRA, Gomes CC. Conservative treatment of calcifying odontogenic cyst: Report of 3 cases. J Oral Maxillofac Surg 2007;65,2353-6.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Indexed In Ebscohost Index Copernicus UlrichsWebOpenJGateGoogle Scholar DOAJ Gale Cengage Learning Research Gate
line
System Developed By Stanford University Arizona State University Simon Fraser University Canadian Centre For Studies In Publishing University of British Columbia - Faculty of Education
W3C XHTML v1.0 Verified W3C verified Valid CSS v2.1 PHP5 Enabled Made On Mac Apache Enabled MySQL Powered
Published by Celesta Software Pvt Ltd