Cyclin D1 Expression in Salivary Gland Tumors: An Immunohistochemical Analysis

Saede Atarbashi Moghadam, Neda Jahani, Sepideh Mokhtari


Background: Cyclin D1 is an essential protein for cell cycle and has been reported to be overexpressed in a variety of cancers. Salivary gland neoplasms make up 1-4% of all human tumors. The present study was performed to evaluate Cyclin D1 expression in salivary gland neoplasms. Method and Materials: Tissue specimens of 15 pleomorphic adenoma and 15 malignant salivary gland tumors including mucoepidermoid carcinoma, adenoid cystic carcinoma and salivary duct carcinoma were examined by immunohistochemistry for Cyclin D1 protein. Cyclin D1 expression was evaluated based on the percentage of nuclei expressing this protein in any intensity. Results:  Twenty-five specimens (83.3%) were negative for this marker and only three pleomorphic adenomas and 2 adenoid cystic carcinoma were positive (16.6%). There was no significant difference between benign and malignant salivary gland tumors. Conclusion: Overexpression of Cyclin D1 probably does not play a role in pathogenesis of benign and malignant salivary gland tumors.


Adenoid Cystic Carcinoma; Cyclin D1; Immunohistochemistry; Mucoepidermoid Carcinoma; Pleomorphic Adenoma; Salivary Gland Neoplasms; Salivary Duct Carcinoma

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