Squamous Cell Carcinoma of the Oral Cavity: A Case Series Analysis of Clinico-Pathological Features

Nitin Saini, Manjunatha BS, Vandana Shah, Deepak Pateel

Abstract


Background: Oral cancer is a major public health issue worldwide and it remains a highly lethal and disfiguring disease. Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity and represents about 90% of all oral malignancies. Increase in incidence and mortality rates is a Global health problem. Squamous cell carcinoma is known to show geographical variation with respect to the age, site, sex and habits of the population. It is a malignant tumor of epithelial origin, with varied regional distribution involved in the biological activity of the neoplasm. Each anatomic site has its own particular spread pattern and prognosis. Hence this study was undertaken to present a comprehensive data on the trends of squamous cell carcinoma of oral cavity. Material and Methods: The study included a total of 127 previously diagnosed cases among a period of 5 years from January 2005 to December 2009. Results: It occurred in an age range from 17 to 86 years and male to female ratio of 3:1. Most commonly affected site was buccal mucosa with ulcero-proliferative growth and large number of cases in the 4th and 5th decades of the life. According to histopathological grading 83% cases were well differentiated, 16% were moderately differentiated and only 1% case was poorly differentiated. Conclusion: Thus squamous cell carcinoma of the oral cavity shows geographical variations with respect to the age, site, sex and habits of the population.


Keywords


Epidermoid carcinoma;Head and neck cancer;Squamous cell carcinoma;Geographic Variations.

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References


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