C-Reactive Protein: Precise, Penurious and Evidential Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma: An In vitro study

Deeepak Chandrakant Kelgandre, Jigna Rakesh Pathak, Shilpa Nilesh Patel, LS Poonja, Niharika Swain

Abstract


Context: The number of patients with oral carcinomas is increasing gradually, although the diagnostic modalities and therapeutic management of oral cancer is improving, the treatment outcome and prognosis of oral cancer have improved little. The absence of definite early warning signs for most head and neck cancers suggests that sensitive and specific biomarkers are likely to be important in screening high-risk patients. Aims: To analyse Serum C Reactive Protein levels in Oral Squamous Cell Carcinoma. Settings and Design: A prospective study was performed in Oral squamous cell carcinoma patients who reported our institute. Serum C Reactive Protein levels were analysed. Methods and Material: 90 histopathologically proven cases of Oral squamous cell carcinoma (study group) and 90 normal healthy individuals (control group) selected for study. Statistical analysis used: Independent Sample t-test, One Sample t-test and One-way Analysis of Variance followed by Tuckey’s POST HOC test. Results: Statistically significant increase in serum C Reactive Protein level was observed in Oral Squamous Cell Carcinoma as histopathological grade increased. Conclusion: Serum C Reactive Protein levels in Oral squamous cell carcinoma may be useful diagnostic and prognostic biomarkers in clinical practice and our data warrant a large-scale study to establish and confirm the clinical utility of the same as a prognostic & diagnostic biomarker.


Keywords


Oral Squamous Cell Carcinoma; C reactive protein; CRP;

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