Hepatitis-B Vaccine: Its Implication to the Field of Medicine

Shivani Ravi, Nadeem Jeddy, Radhika Thangavelu


Hepatitis B infection is a highly communicable viral infection which affects liver. The virus is usually present in the body fluids of infected individuals and can be transmitted through sexual contact, perinatal exposure, blood transfusion, contaminated needles and syringes. Vaccination is mandatory for individuals at high risk as the virus can be transmitted even through insignificant amount of body fluids and result in life-threatening consequences. The existing vaccine developed for this viral infection is highly disputable for its duration of immunity. Studies on immune memory and duration of immunity provided by the vaccine have shown varying results. This review provides an overview on hepatitis B vaccine with emphasis on the duration of immunity provided by the vaccine and its implications in the medical field.


Human Hepatitis; Immune process; Immunization; Liver; Vaccination; Viral infection.

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Mahboobi N, Agha-Hosseini F, Mahboobi N, Safari S, Lavanchy D, Alavian SM. Hepatitis B virus infection in dentistry: a forgotten topic. Journal of Viral Hepatitis 2010;17:307–16.

Thomas D, Devakumari S. Hepatitis B and Dentistry. Pakistan Oral and Dental Journal 2013;33(2):227-31.

Setia S, Singh GR, Kapoor V. Hepatitis B and C infection: Clinical implications in dental practice. European Journal of General Dentistry 2013;2(1):13-9.

Krugman, Davidson M. Hepatitis B vaccine: prospects for duration of immunity. The Yale Journal of Biology and Medicine 1987;60(4):333–9.

Paul N, Peterside O. Hepatitis B Vaccination Rate among Medical Students at the University of Port Harcourt Teaching Hospital (UPTH). World Journal of Vaccines 2015;5:1-7.

Hepatitis B vaccines WHO position paper. Weekly Epidemiological Record 2009;40(84):405–20.

Yano Y. Hepatitis B Vaccines; Efficacy and Necessity of Booster Immunizations. J Hep. 2016;2(1):1-2.

Said ZNA, Abdelwahab KS. Induced immunity against hepatitis B virus. World J Hepatol. 2015;7(12):1660-70.

Leuridan E, Van Damme P. Hepatitis B and the Need for a Booster Dose. Clinical Infectious Diseases 2011;53(1):68–75.

Li H, LI RC, Su-Su L, Jin-Ye Y, Xian-Jia Z, Shu-Sheng W. Persistence of hepatitis B vaccine immune protection and response to hepatitis B booster immunization. World Journal of Gastroenterology 1998;4(6):493-6.

McMahon BJ, Dentinger CM, Bruden D, Zanis C, Peters H, Hurlburt D, et al. Antibody levels and protection after hepatitis b vaccine: results of a 22-year follow-up study and response to a booster dose. The Journal of Infectious Diseases 2009;200:1390–6.

Hudu SA, Malik YA, Niazlin MT, Harmal NS, Adnan A, Alshrari AS, et al. Antibody and immune memory persistence post infant hepatitis B vaccination. Patient Preference and Adherence 2013;7:981–6.

Meerena OVD, Behreb U, Crasta P. Immunity to hepatitis B persists in adolescents 15–16 years of age vaccinated in infancy with three doses of hepatitis B vaccine. Vaccine 2016;34:2745–9.

Bruce MG, Bruden D, Hurlburt D, Zanis C, Thompson G, Rea L, et al. Antibody levels and protection after hepatitis b vaccine: results of a 30-year follow-up study and response to a booster dose. The Journal of Infectious Diseases 2016;214:16–22.

Horowitz MM, Ershler WB, McKinney WP, Battiola RJ. Duration of immunity after hepatitis B vaccination: efficacy of low-dose booster vaccine. Ann Intern Med. 1988;108(2):185-9.

Lu CY, Ni YH, Chiang BL, Chen PJ, Chang MH, Chang LY, et al. Humoral and Cellular Immune Responses to a Hepatitis B Vaccine Booster 15–18 Years after Neonatal Immunization. The Journal of Infectious Diseases 2008;197:1419–26.

Boxall EH, Sira JA, Shuhkri NE, Kelly DA. Long-term persistence of immunity to hepatitis B after vaccination during infancy in a country where endemicity is low. The Journal of Infectious Diseases 2004;190:1264–9.

Jan CF, Huang KC, Chien YC, Greydanus DE, Davies HD, Chiu TY, et al. Determination of immune memory to hepatitis B vaccination through early booster response in college students. Hepatology 2010;51:1547–54.

Livramento A, Cordova CMM, Scaraveli NG, Tonial GC, Spada C, Treitinger A. Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross-sectional study in Blumenau, State of Santa Catarina, Brazil, 2007-2008. Rev Soc Bras Med Trop. 2011;44(4):412-5.


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