A Clinico-Pathological and Immunohistochemical Study of Salivary Gland Tumors: A 5 Year Indian Experience

A Clinico-Pathological and Immunohistochemical Study of Salivary Gland Tumors: A 5 Year Indian Experience

Vineet Gupta, Pratibha Ramani, Chandrasekar T

Abstract

Objectives: To report the clinico-pathological data of salivary gland tumors in Indian population and evaluate common salivary gland tumors using the immunohistochemical markers namely Smooth muscle actin. Materials and Methods: The files from 2004 to 2008 were searched for cases coded as salivary gland tumors. Results: A total of 1855 biopsy specimens were accessioned during the study period. 37 cases were of salivary gland neoplasms, from which 11 were benign and 26 were malignant in nature. Rare presentation of Polymorphous low grade adenocarcinoma in the lower lip and sub-mandibular region has also been reported here. Conclusion: The incidence of malignancies in our cases was higher than benign salivary gland neoplasms. In contrast to the previously existing literature, two unusual presentations have been noticed i.e. third case of Polymorphous low grade adenocarcinoma to be reported in the lower lip and fourth case in the submandibular region. Immunohistochemically, stromal myofibroblasts could be demonstrated only in the tumors with malignant potential. Aggressiveness & prognosis of the tumors can be predicted by measuring the density of myofibroblasts at the invasive front.

References

Speight PM, Barrett AW. Salivary gland tumors. Oral Diseases 2002;8:229-40.

Bruce M. Wenig, Gnepp DR. Polymorphous Low-Grade Adenocarcinoma of minor salivary glands. In: Jennifer Mitchell, editor. Surgical pathology of the salivary glands. Philadelphia: WB Saunders; 1991. 392-408p.

Wei-Yung Yih, James Kratochvil F, Jeffery Stewart CB. Intraoral minor salivary gland neoplasms: Review of 213 cases. Histopathology 2004;44:164-71.

Nagao T, Gaffey TA, Kay PA, Minato H, Serizawa H, Lewis JE. Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. Histopathology 2004;44(2):164-71.

Yutaka Yamazaki, Atsuko Hirai, Makoto Ishikawa, Shingo Moriya, Tadashi Iizuka, Yoshimasa Kitagawa. Polymorphous low-grade adenocarcinoma of submandibular gland origin. Oral Oncol 2005;41:281-3.

Haba R, Kobayashi S, Miki H, Hirakawa E, Saoo K, Iwai T, Mori S, Ohmori M. Polymorphous low-grade adenocarcinoma of submandibular gland origin. Acta Pathol Jpn. 1993;43(12):774-8.

Auclair PL, Ellis GL, Gnepp DR, Wenig BM, Janney CG. Salivary gland neoplasms: General considerations. In: Jennifer Mitchell, editor. Surgical pathology of the salivary glands. Philadelphia: WB Saunders; 1991.135-164p.

Pires FP, Gordon AP, de Almeida OP, Sow-Yeh Chen. Intra-oral minor salivary gland tumors: A clinicopathological study of 546 cases. Oral Oncol 2007;43:463-70.

MHCG de Magalhães, RP de Magalhães, VC de Araújo, SOM de Sousa. Polymorphous low grade adenocarcinoma presenting an uncommon radiographic aspect. Dentomaxillofacial Radiology 2006;35:209-12.

Costea DE, Tsinkalovsky O. Cancer stem cells – new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Diseases 2006;12:443-54.

Ashraf MJ, Azarpira N, Khademi B, Shaghasemi S, Bagheri N. The Value of immunohistochemical markers in Pleomorphic adenoma and Mucoepidermoid carcinoma of salivary gland. Iranian Medical Crescent Journal 2009;11(4):414-8.

Cristiane Furuse, Suzana O. Machado de Sousa, Vera Cavalcanti de Arauijo, Marina Helena Cury Gallottini de Magalhaes, Fabio Daumas Nunes. Myoepithelial cell markers in salivary gland neoplasms. Int J Surg Pathol 2005;13:57-65.

Jones H, Moshtael F, Simpson RH. Immunoreactivity of alpha smooth muscle actin in salivary gland tumours: a comparison with S100 protein. J Clin Pathol 1992;45(10):938–40.

De Araujo, Vera Cavalcanti, de sousa, Suzana Orsini Machado. Application of Immunohistochemistry to the Diagnosis of Salivary Gland Tumors. Lippincott Williams & Wilkins; 2000;8(3):195-202.

John A. Pinkston, Philip Cole. Cigarette Smoking and Warthin's Tumor. Am J Epidemiol 1996;144(2):183-7.

Full Text: PDF HTML XML