“Coenzyme Q10 And Periodontal Health”- A Review

“Coenzyme Q10 And Periodontal Health”- A Review

Sweta Soni, P K Agarwal, Nitin Sharma, Subhash Chander

Abstract

Reactive oxygen species (ROS) not only play an important role in cell signaling and metabolic processes but are also thought to be implicated in the pathogenesis of a variety of inflammatory disorders. Indeed, novel therapies are being developed, specifically aimed at reducing oxidative stress at the tissue and cellular level. Oxidative stress arises within tissues when the normal balance between ROS generation and antioxidant defence shifts in favour of the former, a situation arising from either an excess of ROS and/or a depletion of antioxidants. Periodontitis is a term used to describe an inflammatory process, initiated by the plaque biofilm, that leads to loss of periodontal attachment to the root surface and adjacent alveolar bone and which ultimately results in tooth loss. Periodontal pathogens can induce ROS overproduction and thus may cause collagen and periodontal cell breakdown. When ROS are scavenged by antioxidants, there can be a reduction of collagen degradation. Coenzyme Q10 serves as an endogenous antioxidant which increases the concentration of CoQ10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation.

References

Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochimica Biophysica Acta 1995;(1):195–204.

Al-Hasso. Coenzyme Q10: a review. Hosp Pharm 2001;36(1):51-66.

Raitakari OT, McCredie RJ, Witting P, Griffiths KA, Letter J, Sullivan D, et al. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med 2000;28(7):1100-5.

Aberg F, Appelkvist EL, Dallner G, Ernster L. "Distribution and redox state of ubiquinones in rat and human tissues". Arch Biochem Biophy 1992;295(2):230–4.

Shindo Y, Witt E, Han D, Epstein W, Packer L. "Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin". J Invest Dermatol 1994;102(1):122–4.

Crane F, Hatefi Y, Lester R, Widmer C. "Isolation of a quinone from beef heart mitochondria". Biochimica et Biophysica Acta.1957;25(1):220–1.

Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med 1994;15:s231-40.

Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.

Folkers K. Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res Commun 1996;224:358-61.

Kalenikova EI, Gorodetskaya EA, Kolokolchikova EG, Shashurin DA, Medvedev OS. Chronic administration of coenzyme Q10 limits postinfarct myocardial remodeling in rats. Biochemistry (Mosc) 2007;72:407-15.

Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 1998;68:109-13.

Miles M, Horn P, Miles L, Tang P, Steele P, DeGraw T. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res 2002;22:919-29.

Rauchova H, Drahota Z, Lenaz G. Function of coenzyme Q in the cell: some biochemical and physiological properties. Physiol Res 1995;44:209-16.

Cluis CP, Burja AM, Martin VJ. Current prospects for the production of coenzyme Q10 in microbes. Trends Biotechnol. 2007;25:514-21.

Tomasetti M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J 2001;15:1425-7.

Bentinger M, Tekle M, Dallner G: Coenzyme Q--biosynthesis and functions. Biochem Biophys Res Commun 2010;396(1):74-9.

Mayar P, Hamberger H, Drews J , Defferential effect of Ubiquinone Q7 and Ubiquinone analogs on macrophage activation and experimental infections in granulocytopenic mice. Infection 1980;8:256-61.

Saiki I, Tokushima Y, Nishimura K, Azuma I.Mcrophage activation with Ubiquinone and their related compounds in mice. Int J Vitam Nutr Res 1983;53:312-320.

Folkers K, Shizukuishi S, Takemura K, Drzewoski J, Richardson P, Ellis J, et al. Increase level of IgG in serum of patients treated with coenzymes Q10. Res Commun Chem Pathol Pharmocol 1982;38:335-338.

Slots J. Herpes viruses in periodontal diseases. Periodontol 2000 2005;38:33–62.

Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med 1992:3:31-60.

Bliznakov EG, Chopra RK, Bhagavan HN. Coenzyme Q10 and neoplasia: Overview of experimental and clinical evidence. In: Bagchi D, Preuss HG, editors. Phytopharmaceuticals in Cancer Chemoprevention. Boca Raton: CRC Press; 2004. 599-622p.

Battino M, Bullon P, Wilson M, Newman H. Newman Oxidative injury and inflammatory periodontal diseases: The challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-76.

Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Study of CoQ10 in gingiva from a patients with periodontal disease and evidence for deficiency of Coenzymes Q10.Proc Natl Acad Sci 1974;71:1456-1460.

Hansen IL, Iwamoto Y, Kishi T, Folker K. Bioenergetic in clinical medication IX. Gingival and leukocytic deficiencies of coenzymes Q10 in patients with periodontal disease. Res Commun Chem Pathol Pharma 1976;14:729-38.

Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res Commun Chem Pathol Pharmacol 1975;12:111-23.

Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine. VI. Adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1976; 14:715-9.

Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med 1994; 15:s241-8.

Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine. II. Adjuntive treatment with CoQ10 in periodontal therapy. Res Commun Chem Pathol Pharmacol 1975;12:111-124.

Shizukuishi S, Hanioka T, Tsunemitsu A, Fukunaga Y, Kishi T, Sato N. Clinical effect of Coenzyme 10 on periodontal disease; evaluation of oxygen utilisation in gingiva by tissue reflectance spectrophotometry. Amsterdam: Elsevier; 1986. 359-68p.

McRee JT, Hanioka T, Shizukuishi S, Folkers K. Therapy with Coenzyme Q10 for patients with periodontal disease. 1. Effect of Coenzyme Q10 on subgingival microorganisms. J Dent Health 1993;43:659-66.

Brzozowska TM, Flisykowska AK, OEwitkowska MW, Stopa J. Healing of periodontal tissue assisted by Coenzyme Q10 with Vitamin E: Clinical and laboratory evaluation. Pharmacol Rep 2007;59:251-60.

Dhanasekaran M, Ren J. The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res 2005;2(5):447-59.

Bustos F, Molina JA, Jimenez-Jimenz FJ, Garcia-Redondo A, Gomez-Escalonilla C, Porta-Etessam J, et al. Serum levels of coenzyme Q10 in patients with Alzheimer's disease. J Neural Transm 2000;107(2):233-9.

Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 2007;136(1):72-7.

Ernster, L, Dallner, G. "Biochemical, physiological and medical aspects of ubiquinone function". Biochimica et Biophysica Acta 1995(1):195–204.

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